Cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of comprehensive organismal rejuvenation
- Published
- Accepted
- Subject Areas
- Cell Biology, Computational Biology
- Keywords
- cell lineage tree, aging, rejuvenation
- Copyright
- © 2019 Csordas
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. Cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of comprehensive organismal rejuvenation. PeerJ Preprints 7:e27821v6 https://doi.org/10.7287/peerj.preprints.27821v6
Abstract
The argument makes the case for cell lineage trees and cell tree dynamics to be considered as the central structure and process of understanding organismal level, multicellular biological aging. The limiting challenge of counteracting biological aging is comprehensive organismal rejuvenation. The central theoretical problem of comprehensive biological rejuvenation is to find an algorithm to restore the balance and maintain the healthy dynamics of the aging organismal cell lineage tree. The most comprehensive medical solution of biological aging needs to use individual cell lineage trees as a central tool for diagnosis and treatment.
Author Comment
829 words added to the body of the paper, forming the fourth point of the macro-argument entitled The most comprehensive medical solution of biological aging(s) needs to use individual cell lineage trees as a central tool for diagnosis and treatment, plus corresponding literature references. 11,629 words in total.