Cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of robust organismal rejuvenation
- Published
- Accepted
- Subject Areas
- Cell Biology, Computational Biology
- Keywords
- cell lineage tree, aging, rejuvenation
- Copyright
- © 2019 Csordas
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. Cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of robust organismal rejuvenation. PeerJ Preprints 7:e27821v1 https://doi.org/10.7287/peerj.preprints.27821v1
Abstract
The argument makes the case for cell lineage trees and cell tree dynamics to be considered as the central structure and process of understanding organismal level, multicellular biological aging. The upper limit challenge of counteracting biological aging is robust organismal rejuvenation. The limiting theoretical problem of robust biological rejuvenation is to find an algorithm to restore the balance and maintain the healthy dynamics of the aging organismal cell lineage tree. The most robust medical solution of biological aging needs to use individual cell lineage trees as a central tool for diagnosis and treatment.
Author Comment
This first version contains 5271 words in total and it contains the bulk of the first point of the macro-argument, consisting of 4 points. It is not a finalised draft, does not contain figures, subsequent versions will follow to reach a final format that can be submitted to a journal. The manuscript was made with Pages, hence no line numbers were added since that function is not available.