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Background: Human saliva contains approximately 700 bacterial species but the relatedness of salivary bacteria from parents to adult children is not investigated in humans. The objectives were to investigate the entirety of salivary bacterial DNA profiles and whether and how families share these profiles and also compare these communities between adult parent-off-spring pairs using 16S rRNA gene amplicon sequencing.
Results: The most abundant phyla in two separate families were Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria and Actinobacteria. Family ties explained 13 % of the variance between individuals’ bacterial communities (R2=0.13; P=0.001). Mothers shared more OTUs with their adult children compared to fathers, but this linkage seemed to be weaker in the family with older adult children. We identified 29 differentially abundant genus level OTUs (FDR < 0.05) between the families, which accounted for 31 % of the total identified genus level OTUs
Conclusions: Our results indicate that adult family members share bacterial communities and adult children were more similar to mothers than fathers. Our results suggest implicitly that a similarity in oral microbiome between parent-child pairs is present, but may change over time.
This is a submission to PeerJ for review.
Bacterial taxa with adjusted P-values obtained from SILVA. P-values are adjusted for multiple testing correction in order to reduce false positive results
Bacterial taxa with adjusted P-values obtained from Human Oral Microbiome Database (HOMD). P-values are adjusted for multiple testing correction in order to reduce false positive results