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Esmaile SC, Sousa BG, Blaha CAG, Oliveira JIN.2019. In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study.PeerJ Preprints7:e27560v1https://doi.org/10.7287/peerj.preprints.27560v1
MicroRNA miR-137 single nucleotide polymorphism (rs1625579 SNP) is strongly associated with the worsening of schizophrenia symptoms and is involved in miR-137 gene suppression. MicroRNA miR-137 regulates synaptogenesis, neural plasticity and suppresses a variety of cancertypes. Based on in silico predictions of the current MIR137 Host Gene with and without the SNP, it can be hypothesized that the mutation reversibly inhibits miR-137 gene transcription by steric hindrance due to an alteration on DNA conformation, stability, electrostatic potential, and transcription factor binding sites.
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MIR137HG SEQUENCE (GRCH38.P7) OBTAINED FROM THE SINGLE NUCLEOTIDE POLYMORPHISM DATABASE (DBSNP) WITH CODE RS1625579 SNP