In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study.
1
Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
2
Programa de Pós-Graduação em Ciência e Engenharia de Petróleo, Universidade Federal do Rio Grande do Sul, Natal, Rio Grande do Norte, Brazil
3
Departamento de Biologia Celular e Molecular, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
- Published
- Accepted
- Subject Areas
- Bioinformatics, Computational Biology, Genetics, Neuroscience, Psychiatry and Psychology
- Keywords
- MIR137HG, miR-137, Schizophrenia., in silico
- Copyright
- © 2019 Esmaile et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study. PeerJ Preprints 7:e27560v1 https://doi.org/10.7287/peerj.preprints.27560v1
Abstract
MicroRNA miR-137 single nucleotide polymorphism (rs1625579 SNP) is strongly associated with the worsening of schizophrenia symptoms and is involved in miR-137 gene suppression. MicroRNA miR-137 regulates synaptogenesis, neural plasticity and suppresses a variety of cancertypes. Based on in silico predictions of the current MIR137 Host Gene with and without the SNP, it can be hypothesized that the mutation reversibly inhibits miR-137 gene transcription by steric hindrance due to an alteration on DNA conformation, stability, electrostatic potential, and transcription factor binding sites.
Author Comment
This is a preprint submission to PeerJ Preprints.
