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In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study.

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169 days ago
RT @microRNA_papers: In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study. http…
In silico analysis of miR-137 transcription inhibition in homozygous (T/T) schizophrenic patients: a pilot study. https://t.co/aUyd3Tw1mL
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Supplemental Information

MIR137HG SEQUENCE (GRCH38.P7) OBTAINED FROM THE SINGLE NUCLEOTIDE POLYMORPHISM DATABASE (DBSNP) WITH CODE RS1625579 SNP

DOI: 10.7287/peerj.preprints.27560v1/supp-1

Figure 1: The miR-137 gene inserted in MIR137HG and the distance in base pair of it from the SNP.

DOI: 10.7287/peerj.preprints.27560v1/supp-2

Figure 2: Comparison of DNA stability between wild (G) and mutant (T) sequences.

DOI: 10.7287/peerj.preprints.27560v1/supp-3

Figure 3: (a) Promotor region prediction. (b) Comparison of DNA parameters between wild and mutant sequences.

DOI: 10.7287/peerj.preprints.27560v1/supp-4

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Stephany C Esmaile conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the paper.

Bruno G Sousa performed the experiments, prepared figures and/or tables.

Carlos A G Blaha conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, approved the final draft.

Jonas I N Oliveira analyzed the data, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

The MirR137HG sequence obtained from the Single Nucleotide Polymorphism Database without and within polymorphism G/T are provided in the supplementary file.

Funding

This work was partially financed by the Brazilian Research Agencies CAPES and CNPq. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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