Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
- Published
- Accepted
- Subject Areas
- Animal Behavior, Genetics, Molecular Biology, Neuroscience, Zoology
- Keywords
- insect nervous system, endocrinology, G-protein-coupled receptor (GPCR), neuromodulation, peptide hormone, insulin signaling
- Copyright
- © 2019 Nässel et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior. PeerJ Preprints 7:e27515v2 https://doi.org/10.7287/peerj.preprints.27515v2
Abstract
This review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neuropeptides and peptide hormones in Drosophila, largely due to the rapid developments of powerful genetic methods, imaging techniques and innovative assays. We critically discuss the roles of peptides in olfaction, taste, foraging, feeding, clock function/sleep, aggression, mating/reproduction, learning and other behaviors, as well as in regulation of development, growth, metabolic and water homeostasis, stress responses, fecundity, and lifespan. We furthermore provide novel information on neuropeptide distribution and organization of peptidergic systems, as well as the phylogenetic relations between Drosophila neuropeptides and those of other phyla, including mammals. As will be shown, neuropeptide signaling is phylogenetically ancient, and not only are the structures of the peptides, precursors and receptors conserved over evolution, but also many functions of neuropeptide signaling in physiology and behavior.
Author Comment
Revised figures 4, 10 and supplementary material table 1. Removed section 4.3 ( Ligand “hops” – an alternate to peptide-receptor coevolution).
Supplemental Information
Supplementary Table 1
Flygut-seq EE peptide receptor expression: Expression of receptors for enteroendocrine cell-produced peptides in various regions and cell-types of the adult Drosophila midgut. The midgut is divided into five distinct domains (R1-R5) according to Buchon et al 2013. It is comprised of five different cells: visceral muscles (VM), intestinal stem cells (ISC), enteroblasts (EB), enterocytes (EC) and enteroendocrine (EE) cells. The expression of each receptor is color-coded: the tissue with lowest expression is in yellow, medium expression in orange and highest expression in red. The expression of allatostatin A receptor 1 could not be detected. Data based on Flygut-seq [749] .
Microsoft Word - Suppl. File Appendix 1. R1.docx Supplementary Materials file Appendix 1
Microsoft Word - Suppl. File Appendix 1. R1.docx Brief overview of Drosophila neuropeptides and peptide hormones (Appendix to section 5)
