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Supplemental Information

An elucidation of the links between hormones, DNA methylation, the microbiome, and disease to restore homeostasis to each component through the Genomic Engineering of CRISPR microbes

We reviewed the effects of hormones on DNA methylation. If the microbiome regulates both hormones and DNA methylation, then perhaps through the microbiome diseases can be more readily identified, diagnosed, modeled, and treated. Our purpose for this review, was to find the links between each of the three factors, hormones, DNA methylation, and bacteria, in order to find possible ways to genetically manipulate each into equilibrium to maybe provide alternative diagnosis protocols and treatments for disease.

DOI: 10.7287/peerj.preprints.27509v2/supp-1

PRISMA Flow Chart

A PRISMA flow chart with the analysis of citations included.

DOI: 10.7287/peerj.preprints.27509v2/supp-2

Hillman-Peer-review History

This file includes the peer-review history and the editor's decision for the resubmitted preprint.

DOI: 10.7287/peerj.preprints.27509v2/supp-3

Responses for the review

Responses are included in the file.

DOI: 10.7287/peerj.preprints.27509v2/supp-4

Plagiarism Test Results

The test results report a 1% similarity for the manuscript.

DOI: 10.7287/peerj.preprints.27509v2/supp-5

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Tatiana Hillman analyzed the data, authored or reviewed drafts of the paper, approved the final draft, analyzed literature and research ideas.

Data Deposition

The following information was supplied regarding data availability:

We only performed a literature review without data collection and recordings.


The authors received no funding for this work.

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