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Additional Information

Competing Interests

Colin J Davidson is an employee of Life Technologies.

Iris Schrijver serves as an Academic Editor for PeerJ.

Author Contributions

Lynn M Pique conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Marie-Luise Brennan analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Colin J Davidson performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Frederick Schaefer contributed reagents/materials/analysis tools, reviewed drafts of the paper.

John Greinwald Jr. contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Iris Schrijver conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

(1.) Stanford University Administrative Panels for the Protection of Human Subjects (2.) IRB Approval Numbers IRB-14011 and IRB-8353

Funding

Financial support for this work was provided by Stanford University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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