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Additional Information

Competing Interests

There are no competing interests

Author Contributions

Giulio Spinozzi conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, performed the computation work, authored or reviewed drafts of the paper, approved the final draft.

Valentina Tini conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, performed the computation work, authored or reviewed drafts of the paper, approved the final draft.

Laura Mincarelli contributed reagents/materials/analysis tools, approved the final draft, rNA-seq experiments.

Brunangelo Falini contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Maria Paola Martelli conceived and designed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

https://github.com/giuliospinozzi/creo_pipelines

Funding

The project is funded by the European Research Council (ERC) to Maria Paola Martelli (ContraNPM1AML) and by CINECA (HP10CZ1LLU) to Giulio Spinozzi. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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