Metanacentome: A genomic methodology proposal for the study of nascent metatranscription of the microbiome
- Subject Areas
- Biotechnology, Genomics, Microbiology, Molecular Biology
- Human gut microbiota, metagenomics, metatranscriptomic, microbiome, nacentome, metanacentome
- © 2019 Medina
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. Metanacentome: A genomic methodology proposal for the study of nascent metatranscription of the microbiome. PeerJ Preprints 7:e27252v2 https://doi.org/10.7287/peerj.preprints.27252v2
The gut microbiota has been shown to have an important influence on host health. It has been reported that microbiota composition of each individual is stable across the adult life, but it may varies between individuals. Moreover, human gut microbiota composition differs across geography, according to host genetics, dietary habits, age, ethnic origin, geographic location and lifestyle. Nevertheless, gene composition or functional capacity is highly conserved across individuals, phenomenon known as functional redundancy. Although metatranscriptomics have the potential of study the mature mRNA from a microbiome sample, it is not easy to identify which bacteria is actively transcribing the genes who drives the molecular expression. The use of genome-wide methodologies to study the active mRNA synthesis seem to be useful to identify the bacterias who drives gene expression in microbiota environment.
Version 2 has English corrections.