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ShapeGTB: The role of local DNA shape in prioritization of functional variants in human promoters with machine learning

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62 days ago
ShapeGTB: The role of local DNA shape in prioritization of functional variants in human promoters with machine learning https://t.co/5gAljhq5Ps
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Supplemental Information

ROC curves for random train-test split

DOI: 10.7287/peerj.preprints.27199v1/supp-5

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Maja Malkowska conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Julian Zubek conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Dariusz Plewczynski conceived and designed the experiments, authored or reviewed drafts of the paper, approved the final draft.

Lucjan S Wyrwicz conceived and designed the experiments, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

Github: https://github.com/zubekj/ShapeGTB

Funding

This work was co-supported by the Polish National Science Centre (2014/15/B/ST6/05082 to Julian Zubek & Dariusz Plewczynski and DEC-2012/06/M/NZ2/00112 to Maja Malkowska & Lucjan S. Wyrwicz), Foundation for Polish Science (TEAM to Dariusz Plewczynski), the Department of Science and Technology, India under Indo-Polish/Polish-Indo project (DST/INT/POL/P-36/2016 to Dariusz Plewczynski), European Cooperation in Science and Technology action (COST BM1405, BM1408) and 1U54DK107967-01 “Nucleome Positioning System for Spatiotemporal Genome Organization and Regulation” grant within 4DNucleome NIH program (to Julian Zubek & Dariusz Plewczynski). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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