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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Jinyong Ju conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Du Yu performed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Feng Xue contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Yong Zhao analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Weizhe Shi analyzed the data.

Mingmang Pan contributed reagents/materials/analysis tools.

Guo Tang contributed reagents/materials/analysis tools.

Haijun Xiao conceived and designed the experiments, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The animal experiment protocol was approved by the Bioethics Committee of East China Normal University (Animal Experiment License:SYXK 2010-0094).

Data Deposition

The following information was supplied regarding data availability:

The raw data has been supplied as a supplementary file.

Funding

This work was supported by Science and Technology Commission of Shanghai Municipality(No.15411 970900). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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