The involvement of human endogenous retroviruses K (HERV-K) in aging processes via induction of inflammation
- Published
- Accepted
- Subject Areas
- Cell Biology, Developmental Biology, Genetics, Molecular Biology
- Keywords
- herv-k, endogenous retroviruses, lncrRNA, p53, NF-kB, chronic inflammation, epigenetics, aging
- Copyright
- © 2019 Ochirov
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. The involvement of human endogenous retroviruses K (HERV-K) in aging processes via induction of inflammation. PeerJ Preprints 7:e26998v2 https://doi.org/10.7287/peerj.preprints.26998v2
Abstract
This detailed analysis provides an insight into aging processes in the human organism. The developmental program that controls the regulation of gene expression through epigenetic modifications leads to cellular senescence in the latter life. This epigenetic development system uses endogenous retroviruses and other retrotransposons as control elements that regulate gene expression through non-coding RNAs. Interaction with sex hormones causes activation of human endogenous retroviruses K (HERV-K) inducing a prolonged innate immune response and therefore chronic inflammation leading to complex changes in the signaling pathways inside the cell and thus contributes to age-associated phenotype in the form of tissue deterioration and may cause a spontaneous transition of tissues to cancer state.
Author Comment
This is a preprint submission to PeerJ Preprints. Small changes in "Long non-coding RNAs in the epigenetic regulation by human endogenous retroviruses"