Maternal temperature exposure triggers emotional and cognitive disorders and dysregulation of neurodevelopment genes in fish
- Published
- Accepted
- Subject Areas
- Animal Behavior, Aquaculture, Fisheries and Fish Science, Developmental Biology, Genomics, Climate Change Biology
- Keywords
- behavior, egg, transcriptome, salmonid, trout, stress, temperature, intergenerational, cognition, emotion
- Copyright
- © 2018 Colson et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2018. Maternal temperature exposure triggers emotional and cognitive disorders and dysregulation of neurodevelopment genes in fish. PeerJ Preprints 6:e26910v1 https://doi.org/10.7287/peerj.preprints.26910v1
Abstract
Fish are sensitive to temperature, but the intergenerational consequences of maternal exposure to high temperature on offspring adaptive behaviour and underlying mechanisms are unknown. Here we show that a thermal maternal stress induces emotional and cognitive disorders in offspring. Thermal stress in mothers triggered the inhibition of fear responses and decreased spatial learning abilities in progeny. Impaired behavioural phenotypes were associated with the dysregulation of several genes known to play major roles in neurodevelopment, including auts2, a key gene for neurodevelopment, more specifically neuronal migration and neurite extension, and critical for the acquisition of neurocognitive function. In addition, our analysis revealed the dysregulation of another neurodevelopment gene (dpysl5) as well as genes associated with human cognitive disorders (arv1,plp2). We observed major differences in maternal mRNA abundance in the eggs following maternal exposure to high temperature indicating that some of the observed intergenerational effects are mediated by maternally-inherited mRNAs accumulated in the egg. Together, our observations shed new light on the intergenerational determinism of fish behaviour and associated underlying mechanisms. They also stress the importance of maternal history on fish adaptive capacities in a context of global climate changes.
Author Comment
This is a submission to PeerJ for review.
Supplemental Information
Types of malformations
Effects of rearing temperature before ovulation (12°C and 17°C) on the occurrence of different types of embryonic malformation (%) at yolk-sac resorption. T: torsion, YSD: Yolk-sac resorption defects, O: Others.
Dataset of mortality rates, malformed fry, oocytes cortisol levels and behavioural parameters in 17°C and 12°C groups
Sheet 1: dataset of mortality rates; Sheet 2: dataset of malformed fry; Sheet 3: dataset of oocytes cortisol levels; Sheet 4: dataset of the novel-tank test; Sheet 5: dataset of the spatial learning test; Sheets 6-7: datasets of the memory test (3 days after the last learning trial)