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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Nikolay B Pestov conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Daniel V Kalinovsky conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, reviewed drafts of the paper.

Tatyana D Larionova performed the experiments, analyzed the data, prepared figures and/or tables, reviewed drafts of the paper.

Alia Z Zakirova performed the experiments, prepared figures and/or tables, reviewed drafts of the paper.

Nikolai N Modyanov conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Irina A Okkelman conceived and designed the experiments, performed the experiments.

Tatyana V Korneenko performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Immunization of rabbits has been approved by Animal Care and Use Review Board of Shemyakin-Ovchinnikov Institute of Bioorganic Chemisrty, protocol No 15/2011.

Data Deposition

The following information was supplied regarding data availability:

The raw data are included in the manuscript.

Funding

These studies were supported by MCB RAS and Russian Foundation for Basic Research (grant No 16-04-01755). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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