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Influence of mutation bias and hydrophobicity on the substitution rates and sequence entropies of protein evolution

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159 days ago
Influence of mutation bias and hydrophobicity on the substitution rates and sequence entropies of protein evolution https://t.co/Pfl7TI8XRH
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Supplemental Information

Source codes of the program Prot_Evol

The source code (in C programming language) can be compiled and run as explained in the README file included in the package.

DOI: 10.7287/peerj.preprints.26868v1/supp-1

Additional Information

Competing Interests

Ugo Bastolla is an Academic Editor for PeerJ.

Author Contributions

María José Jiménez-Santos performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Miguel Arenas analyzed the data, authored or reviewed drafts of the paper, approved the final draft.

Ugo Bastolla conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

The program Prot_evol is freely available for download at the url https://ub.cbm.uam.es/prot_fold_evol/prot_fold_evol_soft_main.php#Prot_Evol

The multiple sequence alignments from which the leftmost plots of Fig.1 have been obtained are available at https://github.com/wilkelab/therm_constraints_rate_variation/

Funding

This work was supported by the Spanish Ministry of Economy through grants BIO2016-79043 and BFU2012-40020. MA was supported by the Ramón y Cajal Grant RYC-2015-18241 from the Spanish Government. Research at CBMSO is facilitated by Fundación Ramón Areces. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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