Protocol: The effect of whole-grain dietary intake on non-communicable diseases: A systematic review, multivariate meta-analysis and dose-response of prospective cohorts, cross-sectional, case-control and intervention studies

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1 Human Nutrition Research Centre, University of Newcastle-upon-Tyne, Newcastle Upon Tyne, Tyne and Wear, United Kingdom
2 Modelling, Evidence & Policy group, University of Newcastle-upon-Tyne, Newcastle Upon Tyne, Tyne and Wear, United Kingdom
3 Plant and Microbial Science Research group, University of Newcastle-upon-Tyne, Newcastle Upon Tyne, Tyne and Wear, United Kingdom
DOI
10.7287/peerj.preprints.26710v1
Published
Accepted
Subject Areas
Agricultural Science, Nutrition, Public Health, Science and Medical Education, Statistics
Keywords
Whole-grains, Public Health, Nutrition, Food science, Dietary fiber, Non-communicable disease, Biomarkers, Type 2 diabetes, Cardiovascular disease, obesity
Copyright
© 2018 Iqbal et al.
Licence
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
Cite this article
Iqbal WA, Stewart GB, Smith AJ, Seal CJ. 2018. Protocol: The effect of whole-grain dietary intake on non-communicable diseases: A systematic review, multivariate meta-analysis and dose-response of prospective cohorts, cross-sectional, case-control and intervention studies. PeerJ Preprints 6:e26710v1

Abstract

The proposed protocol is for a systematic review and meta-analysis on the effects of whole-grains (WG) on non-communicable diseases such as type 2 diabetes, cardiovascular disease, hypertension and obesity. The primary objectives is to explore the mechanisms of WG intake on multiple biomarkers of NCDs such as fasting glucose, fasting insulin and many others. The secondary objective will look at the dose-response relationship between these various mechanisms. The protocol outlines the motive and scope for the review, and methodology including the risk of bias, statistical analysis, screening and study criteria.

Author Comment

The proposed protocol is for a systematic review and meta-analysis on the effects of whole-grains (WG) on non-communicable diseases such as type 2 diabetes, cardiovascular disease, hypertension and obesity.