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Making of fusion genes in cancer: An in-silico study of mechanism of chromosomal translocations

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My preprint has been published today in @PeerJPreprints https://t.co/YAJ6sDJa4v #Bioinformatics #ComputationalBiology
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Supplemental Information

Supplementary tables showing Data retrieval using TICdb and analysis of physico-chemical properties of fusion sequences and respective controls using DiProGb software

Tables 1-4 show the nucleotide sequence of fusion partners retrieved from TICdb for all four fusion pairs i.e. BCR/ABL, PML/RARA, AML/ETO, and CBFB/MYH11.

Tables 5-8 show analysis of physico-chemical parameters/AT% of fusion sequences (100 &1000 bp upstream and downstream FS) for all four fusion pairs.

Tables 9-16 show analysis of physico-chemical parameters/AT% of control sequences (100 &1000 bp upstream and downstream FS).

DOI: 10.7287/peerj.preprints.26571v1/supp-1

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Kiran Lalwani conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, performed the computation work, authored or reviewed drafts of the paper, approved the final draft.

Shivani Sheth conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, performed the computation work, authored or reviewed drafts of the paper, approved the final draft.

Inayatullah Sheikh conceived and designed the experiments, analyzed the data, performed the computation work, authored or reviewed drafts of the paper, approved the final draft, expert in Software tools selected for the proposed study.

Afzal Ansari conceived and designed the experiments, analyzed the data, performed the computation work, authored or reviewed drafts of the paper, approved the final draft, expert in Software tools selected for the proposed study.

Fulesh Kunwar analyzed the data, authored or reviewed drafts of the paper, approved the final draft.

Jayshankar Das conceived and designed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Sonal R Bakshi conceived and designed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft, selection of candidate gene pairs for non random involvement in fusion.

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any data or code.

The computer algorithms provided value for proposed parameters in the context of the selected gene pairs.

Funding

This work was supported by Nirma University The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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