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Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain

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161 days ago
Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain https://t.co/tpWMn7Oejv
RT @Romantceva: My preprint has been published today in @PeerJPreprints https://t.co/aMyAqSoUxZ #DevelopmentalBiology #N.. https://t.co/kUL…
240 days ago
Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra but not the ventral tegmental area in mouse brain https://t.co/CbTVxUfyKD
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Supplemental Information

Raw data for the number of TH-positive neurons in SN of alpha-synuclein knockout and control WT mice in embryogenesis and number of TH-positive neurons in SN and VTA on E13.5 day

DOI: 10.7287/peerj.preprints.26547v2/supp-1

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Tatiana V Tarasova performed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Olga A Lytkina performed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Valeria V Goloborshcheva performed the experiments, contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper, approved the final draft.

Larisa N Skuratovskaya analyzed the data, authored or reviewed drafts of the paper, approved the final draft.

Alexandr I Antohin analyzed the data, authored or reviewed drafts of the paper, approved the final draft.

Ruslan K Ovchinnikov performed the experiments, authored or reviewed drafts of the paper, approved the final draft.

Michail S Kukharsky conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Bioethics committee of Institute of Physiologically Active Compounds, Russian Academy of Sciences provided full approval for this research

Data Deposition

The following information was supplied regarding data availability:

The raw data/code has uploaded as a Supplemental file.

Funding

This study was supported by the Russian Foundation for Basic Research (grant № 16-34-00530) and the Federal Agency for Scientific Organizations program for support the bioresource collections. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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