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Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease.

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33 days ago
Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease. https://t.co/qo31wDZFgx
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Supplemental Information

The relative expression levels of proteins present in the substantia nigra of rats at embryonic days 11, 12, 13 and 14, obtained through iTRAQ

DOI: 10.7287/peerj.preprints.26443v2/supp-1

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

William D Mitchell performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Rowan P Orme performed the experiments, analyzed the data.

Sarah R Hart conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Rosemary A Fricker conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Tissues were collected from pregnant rats and their embryos that had been euthanised using approved Schedule 1 methods as defined in the Animals (Scientific Procedures) Act 1986 (UK).The ASPA licence type is: Establishment licence for Keele University.

Funding

This research was funded by an EPSRC Centre for Doctoral Training studentship awarded to William D. Mitchell. The dataset used in the analysis was generated from research funded by Parkinson’s UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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