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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Ganesh R Iyer conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, performed the computation work.

Sapoonjyoti Duttaduwarah wrote the paper, literature review.

Ashish Sharma conceived and designed the experiments, wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:


This work was supported by NCI QIN grant (1U01CA187013-01, (Resources for development and validation of Radiomic Analyses & Adaptive Therapy), NCIP/Leidos CTIIP Contract (caMicroscope —A Digital Pathology Integrative Query System), and the Google Summer of Code (2014, 2015, 2016). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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