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Supplemental Information

Confirmation of the sequence of 2 C-terminal fragments of MK identified in samples of MK incubated for 15 min in the presence of a human umbilical vein ring via tandem mass spectroscopy (LC-MS/MS)

The found N-terminal fragments of “n” residues (bn, in red) or of C-terminal ones (yn, in blue) of the postulated MK fragments are indicated along the mass/charge scale, thus confirming the identity of the parent peptides Gly-Pro-BK (A) and Lys-Gly-Pro-BK (B).

DOI: 10.7287/peerj.preprints.2641v1/supp-1

Raw data

Individual replicates for each averaged data point in figs. 1-3, 7 and 8.

DOI: 10.7287/peerj.preprints.2641v1/supp-2

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Xavier Charest-Morin conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Hélène Bachelard conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Melissa Jean performed the experiments, analyzed the data, reviewed drafts of the paper.

Francois Marceau conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

CHU de Québec, Comité d’éthique de la recherche, granted ethical approval to carry out the study within its facilities (file number: 2012-323).

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

All surgical and experimental procedures were reviewed and approved by the Animal Care and Handling Committee of Laval University, in accordance with the Canadian Council on Animal Care (file no. 2012-223).

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate, collect or analyse any raw data or code.

Funding

The work was supported by the the grant MOP-93773 from the Canadian Institutes of Health Research to FM and HB and the Fonds de recherche du Québec-Santé (Studentship award to XCM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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