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Additional Information

Competing Interests

We have no competing interest in the publication of this paper.

Author Contributions

Steve S.B. Wotton conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Xiaofan Zhang performed the experiments, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Justin J.L. McKinstry performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Antonio Velarde performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper, arranges part of the trial in Spain.

Toby G Knowles analyzed the data, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Our UIN number is UIN/13/037 granted by the University of Bristol Ethical Review Group.

Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Our UIN number is UIN/13/037 granted by the University of Bristol Ethical Review Group.

Funding

These experiments were funded as part of an MSc student project by the University of Bristol and by a commercial sponsor. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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