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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Luciana L A Ventura conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Nathália C L Fortes performed the experiments.

Helton C Santiago performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Marcelo Vidigal Caliari performed the experiments, contributed reagents/materials/analysis tools, prepared figures and/or tables.

Maria A Gomes conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Dirce R Oliveira conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Ethics Committee on Animal Use (CEUA) provided full approval for this research (136/13).

Data Deposition

The following information was supplied regarding data availability:

The raw data or code is included in the manuscript.

Funding

This work was supported by the Fundação de Amparo à Pesquisa do Estado de Minas Gerais – FAPEMIG (grant PPM00140-14), Conselho Nacional de Desenvolvimento Científico e Tenológico - CNPq (grant 478939/2012-4), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES (doctoral fellowship). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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