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Additional Information

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Torbjørn Rognes conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Tomáš Flouri conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Ben Nichols conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Christopher Quince conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Frédéric Mahé conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

https://github.com/torognes/vsearch

https://github.com/torognes/vsearch-eval

Funding

This research was supported in part with computational resources at the University of Oslo provided by NOTUR project NN9383K and funded by the Research Council of Norway. BN was funded by BBSRC CASE studentship supported by Unilever. CQ was funded through the MRC Cloud Infrastructure for Microbial Bioinformatics (CLIMB) project (MR/L015\-080/1) through fellowship (MR/M50161X/1) FM was supported by the Deutsche Forschungsgemeinschaft (grant #DU1319/1-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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