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Additional Information

Competing Interests

Bruno Lomonte serves as an Academic Editor for PeerJ. Christopher Clouser and Francois Vigneault are employees of Juno Therapeutics, Seattle, Washington, United States of America and Sonia Timberlake is an employee of Finch Therapeutics, Somerville, Massachusetts, United States of America. The authors declare no other competing interests.

Author Contributions

Andreas H Laustsen conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Mikael Engmark analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Christopher Clouser performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Sonia Timberlake performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Francois Vigneault conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

José María Gutiérrez conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Bruno Lomonte conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Comité Institucional para el Uso y Cuido de Animales (CICUA), Universidad de Costa Rica.

Approval number 82-08 (experiments on mouse toxicity tests and neutralization by antivenoms).

Data Deposition

The following information was supplied regarding data availability:

The raw sequencing data is irrelevant for the reader as this is only used to isotype immunoglobulins - not to deduct any information about specific sequences.

Funding

The following institutions and foundations supported the research: Juno Therapeutics Inc., Instituto Clodomiro Picado, Universidad de Costa Rica, and the Novo Nordisk Foundation (NNF13OC0005613 and NNF16OC0019248). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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