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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Huaibin Miao conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Jun Fu conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables.

Zhihui Qian conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Luquan Ren contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Lei Ren contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

1. The Institutional Review Board Committee of Jilin University

2. This study was conducted with the approval of the Institutional Review Board Committee of Jilin University, Changchun, P.R. China (NO. 20140418).

Data Deposition

The following information was supplied regarding data availability:

The raw data has been supplied as a supplementary file

Funding

This work was supported by the project of National Natural Science Foundation of China (No.51105167 & 51475202) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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