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Additional Information

Competing Interests

The authors declare that they have no competing interests. Samuel A Hurley is an employee of Synaptive Medical, Toronto, ON, Canada.

Author Contributions

Tobias C Wood conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Camilla Simmons performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Samuel A Hurley contributed reagents/materials/analysis tools, reviewed drafts of the paper, provided the DESPOT sequences for the Agilent scanner.

Anthony C Vernon conceived and designed the experiments, reviewed drafts of the paper.

Joel Torres analyzed the data.

Flavio Dell'Acqua reviewed drafts of the paper, assisted with the diffusion sequence for the Agilent scanner.

Steve C R Williams conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Diana Cash conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

All experiments were performed under approval of the local KCL ethics committee and the UK Animals (Scientific Procedures) Act 1986, according to the Home Office Project license no 70/8480 (held by Diana Cash).

Data Deposition

The following information was supplied regarding data availability:

1) Code - http://github.com/spinicist/QUIT -

2) Quantitative maps & stats images - https://figshare.com/articles/Whole-Brain_Ex-Vivo_Quantitative_MRI_of_the_Cuprizone_Mouse/3495848

Funding

The study received funding from the MRC (grant code G0800298). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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