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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Benjamin D Kaehler conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Von Bing Yap conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Gavin A Huttley conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

Software is available on Bitbucket at

https://bitbucket.org/nonstationary/codon

Funding

We acknowledge funding support from the Australian Research Council and the National Health and Medical Research Council awarded to G. A. H. and V. B. Y., and from the Singapore Ministry of Education (AcRF Grant R-155-000-127-112) awarded to V.B.Y. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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