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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Pasquale Nino conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, performed the computation work.

Silvia Vanino performed the experiments.

Flavio Lupia performed the experiments, wrote the paper, prepared figures and/or tables, performed the computation work.

Guido D'Urso performed the experiments, reviewed drafts of the paper.

Carlo De Michele performed the experiments, reviewed drafts of the paper.

Giuseppe Pulighe performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, performed the computation work.

Guido Bonati conceived and designed the experiments, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

https://figshare.com/account/home#/data

Funding

This work was carried out inside the FORBIO H2020 project GRANT AGREEMENT NUMBER — 691846. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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