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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Changsu Kong conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Jong Young Ahn performed the experiments, analyzed the data, wrote the paper.

Beob G Kim conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Institutional Animal Care and Use Committee of Konkuk University reviewed and approved all protocols (KU13188) used in the present study.

Data Deposition

The following information was supplied regarding data availability:

The raw data has been supplied as a supplementary file.

Funding

This paper was supported by the KU Research Professor Program of Konkuk University. The authors gratefully acknowledge CJ CheilJedang Bio Co., Ltd (Seoul, Republic of Korea) for providing L-Met. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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