Reporting quality of animal experiments of gastric cancer based on the ARRIVE guidelines

Yali Liu; Yuchen Feng; Lili Zhang; Xiaohuan Feng; Qin Feng; JIngyi Luo; Zhaodi Bai; Haoyu Wu; Xin Tian; Yumin Li

doi:10.7287/peerj.preprints.2049v1

Reporting quality of animal experiments of gastric cancer based on the ARRIVE guidelines

Yali Liu^1,2, Yuchen Feng³, Lili Zhang³, Xiaohuan Feng³, Qin Feng³, JIngyi Luo¹, Zhaodi Bai¹, Haoyu Wu⁴, Xin Tian⁵, Yumin Li ⁶

1 Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou University, Lanzhou, Gansu, China

2 Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, Gansu, China

3 The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou, Gansu, China

4 School Clinic,the First Hospital,Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, Shanxi, China

5 The First Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou, Gansu, China

6 The Second Hospital of Lanzhou University, Key Laboratory of Digestive System Tumors, Gansu Province, Lanzhou University, Lanzhou, Gansu, China

DOI: 10.7287/peerj.preprints.2049v1

Published: 2016-05-17
Accepted: 2016-05-17

Subject Areas: Veterinary Medicine, Gastroenterology and Hepatology, Oncology, Translational Medicine, Statistics
Keywords: Animal experiments, gastric cancer, ARRIVE guidelines

Copyright: © 2016 Liu et al.
Licence: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.

Cite this article: Liu Y, Feng Y, Zhang L, Feng X, Feng Q, Luo J, Bai Z, Wu H, Tian X, Li Y. 2016. Reporting quality of animal experiments of gastric cancer based on the ARRIVE guidelines. PeerJ Preprints 4:e2049v1 https://doi.org/10.7287/peerj.preprints.2049v1

Abstract

Objective: The aim of this study was to use the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to evaluate the quality of reporting of recent gastric cancer animal experiments. Materials and Methods: A literature search of studies was performed using the Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text Database, and Wanfang Database from January 2010 to December 2012. We extracted data using pre-prepared Excel data-extraction forms. Reporting quality was evaluated based on the ARRIVE guidelines. Results: Of the 1816 studies that were identified by our search, 170 were subjected to quantitative analysis using the ARRIVE guidelines. The results of the evaluation based on the ARRIVE guidelines were that 132 studies (77.61%) provided an accurate and concise description of baseline conditions and clinical conditions. Only 2 (1.18%) papers provided relevant certificates of ethical review or institutional guidelines, and 2 (1.18%) papers provided an explanation of animal experiments requiring algorithms and formulas for sample size. Forty-seven (27.65%) studies described in detail how animals were assigned to each experimental group, including the randomization procedure, 2 (1.18%) reported whether blinding was used, and 15 (8.82%) evaluated the limitations of the study. Conclusions: The reporting quality of recent animal experiments of gastric cancer is inadequate. We should improve not only the quality of the methodology but also the reporting quality of the animal experiments.