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Additional Information

Competing Interests

The authors declare that they have no competing interests

Author Contributions

Pauline Frizelle conceived and designed the experiments, analyzed the data, wrote the paper.

Jennifer Harte conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables.

Kathleen O'Sullivan analyzed the data, contributed reagents/materials/analysis tools.

Paul Fletcher conceived and designed the experiments, reviewed drafts of the paper.

Fiona E. Gibbon conceived and designed the experiments, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Clinical Research Ethics Committee of the Cork Teaching Hospitals

Data Deposition

The following information was supplied regarding data availability:

The raw data is supplied within the manuscript.

Funding

This work was supported by a Health Research Award, research grant HRA_POR /2012/68 from the Irish Health Research Board. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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