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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Edwin Mulder conceived and designed the experiments, wrote the paper, reviewed drafts of the paper.

Alexandra Noppe wrote the paper, reviewed drafts of the paper.

Ulrich Limper wrote the paper, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Ethics Committee of the Medical Council of North Rhine, Duesseldorf, Germany

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any raw data.

Funding

European Space Agency (ESA) contract No. 4000113871/15/NL/PG Bed rest studies are 'directed research' funded by Space Agencies. Based on the standarization needed, study design and data collection phases are pre-identified.


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