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Supplemental Information

Part of raw data for Figure 1

DOI: 10.7287/peerj.preprints.1769v1/supp-1

Part of raw data for Figure 2

DOI: 10.7287/peerj.preprints.1769v1/supp-2

Part of raw data for Figure 2

DOI: 10.7287/peerj.preprints.1769v1/supp-3

Part of raw data for Figure 3

DOI: 10.7287/peerj.preprints.1769v1/supp-4

Part of raw data for Figure 4

DOI: 10.7287/peerj.preprints.1769v1/supp-5

Part of raw data for Figure 5

DOI: 10.7287/peerj.preprints.1769v1/supp-6

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Yan Tang conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Binping Luo conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables.

Zhili Deng prepared figures and/or tables.

Ben Wang prepared figures and/or tables.

Fangfen L Liu contributed reagents/materials/analysis tools.

Jinmao Li reviewed drafts of the paper.

Wei Shi contributed reagents/materials/analysis tools.

Hongfu Xie contributed reagents/materials/analysis tools.

Ji Li conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Ethics Committee of the Center, Scientific Research Center with Animal Models, Xiangya Hospital, Central South University approved all experimental protocols used in our study (No:2011-01-05).

Data Deposition

The following information was supplied regarding data availability:

The data was deposited in Xiangya Hospital, Central South University.

Funding

This research was supported by the National Natural Science Foundation of China (81171520, 81371756, 81271775, 81402623), Hunan Provincial Natural Science Foundation of China (2015JJ1023). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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