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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Jingjie Yang conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables.

Eoin N Leen conceived and designed the experiments, performed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Francois F Maree analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Stephen Curry conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

Protein Data Bank

PDB ID 4X2Y

http://www.rcsb.org/pdb/explore/explore.do?structureId=4x2y

Funding

This work was supported by the award of a Wellcome Trust studentship to Eoin N. Leen) (reference: 083248/2/07/2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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