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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Jimmy C Kromann performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Anders S Christensen performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, reviewed drafts of the paper.

Qiang Cui analyzed the data, reviewed drafts of the paper.

Jan H. Jensen conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

All input and output files are available as supplementary information on Figshare https://dx.doi.org/10.6084/m9.figshare.2157379

Funding

JCK acknowledges support from the University of Copenhagen. The work at UW-Madison is supported by the NIH grant R01-GM106443. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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