TY - JOUR UR - https://doi.org/10.7287/peerj.preprints.1723v2 DO - 10.7287/peerj.preprints.1723v2 TI - DChIPRep, an R/Bioconductor package for differential enrichment analysis in chromatin studies AU - Chabbert,Christophe D AU - Steinmetz,Lars M AU - Klaus,Bernd DA - 2016/02/09 PY - 2016 KW - Bioinformatics KW - Computational Biology KW - Genomics KW - ChiP–Seq KW - Chromatin KW - Histone–Modifications KW - Differential Enrichment KW - Statistics AB - The genome–wide study of epigenetic states requires the integrative analysis of histone modification ChIP–seq data. Here, we introduce an easy–to–use analytic framework to compare profiles of enrichment in histone modifications around classes of genomic elements, e.g. transcription start sites (TSS). Our framework is available via the user–friendly R/Bioconductor package DChIPRep. DChIPRep uses biological replicate information as well as chromatin Input data to allow for a rigorous assessment of differential enrichment. DChIPRep is available for download through the Bioconductor project at http://bioconductor.org/packages/DChIPRep. Contact DChIPRep@gmail.com VL - 4 SP - e1723v2 T2 - PeerJ PrePrints JO - PeerJ PrePrints J2 - PeerJ PrePrints SN - 2167-9843 ER -