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Background: Childhood immunization is the most effective preventive services, and is critical to monitor and evaluate. A study reported an association between parental satisfactions with pediatric care and up-to-date immunization at 24 months independent of maternal age, race, and education. In addition to promoting utilization, satisfaction may increase involvement in the health care process. Health system factors included inconvenient clinic hours, dates or locations, waiting lines, and conflicting information. The inconvenience of clinic hours dates of immunization clinics, and locations of clinics were reported by 75% of parents. Objectives of the study: to determine the relationship between maternal knowledge about vaccination and satisfaction about vaccination program. Methods: A cross section study was conducted on three hundred and thirty five mothers chosen from PHCC participating in the study by providing information on satisfaction about the program and their knowledge about vaccination. Result: Inappropriate knowledge was reported by most of mothers (84.8%). Moreover, 95.2% of mothers were satisfied with childhood immunization services in primary healthcare center. Conclusion: The study shows that there was no statistically significant relation between maternal satisfaction with childhood immunization services and knowledge score, priorities from client's perspectives are changing, so on- going monitoring of client satisfaction is the cornerstone to improve quality of care.