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Additional Information

Competing Interests

The authors report no conflict of interest in this study. V. Pérez has been a consultant to or has received honoraria or grants from AstraZeneca, Bristol-Myers-Squibb, Janssen Cilag, Lundbeck, Merck, Otsuka, Roche, Servier and Medtronic. Claude Robert Cloninger is an Academic Editor for PeerJ.

Author Contributions

Liliana Galindo conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Francisco Pastoriza conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Daniel Bergé conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Anna Mané conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Marisol Picado contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Antonio Bulbena contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Patricia Robledo analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Victor Pérez contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Oscar Vilarroya conceived and designed the experiments, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Claude Robert Cloninger conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

CEIC- Parc de Salut Mar

2011/4141/I

Funding

We would like to acknowledge the “Red de Transtornos Adictivos” of the Instituto de Salud Carlos III (RD12/0028/0009) and the “Centro de Investigación Biomédica en Red de Salud Mental” (CIBERSAM G21). LG is a recipient of the “Río Hortega” fellowship from the Instituto de Salud Carlos III (ISCIII-FIS, CM14/00111). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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