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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Domingas Conceição performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

João da Silva conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Juan Cisneros conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Roberto Iannuzzi conceived and designed the experiments, analyzed the data, wrote the paper, reviewed drafts of the paper.

Bartolomeu C Viana conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Gilberto Saraiva conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Joel Sousa conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Paulo T Freire analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables.

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any raw data.

Funding

G.D. Saraiva, Ph.D, acknowledges the support from the MCTI/CNPQ/Universal 14/2014 (Grants#449471/2014-4) and the PQ – 2014 (Grants#306631/2014-8), R. Iannuzzi thanks CNPq for the grants (PQ 309211/2013-1) and PTCF thanks CNPq. The authors also wish to thank the following Brazilian institutions CAPES, FAPESPI and FUNCAP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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