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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Emilio Marquez-Contreras conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Lourdes López García-Ramos performed the experiments, reviewed drafts of the paper.

Nieves Martell-Claros performed the experiments, reviewed drafts of the paper.

Vicente F Gil-Guillen conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Sara Márquez-Rivero performed the experiments, reviewed drafts of the paper.

Elena Pérez-López performed the experiments, reviewed drafts of the paper.

Maria Angeles Garrido-Lopez performed the experiments, reviewed drafts of the paper.

Celia Farauste performed the experiments, reviewed drafts of the paper.

Adriana Lopez-Pineda wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Jose Joaquín Casado-Martínez performed the experiments, analyzed the data, reviewed drafts of the paper.

Concepcion Carratala-Munuera conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The study was conducted following the ethical standards for clinical research of the Declaration of Helsinki. The study was approved by the Research Committee of the Health Area of Huelva.

An approval letter was given on 10th September 2007 by the Ethics Committee of Hospital Juan Ramón Jimenez (Huelva, Spain).

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any raw data.

Funding

The authors received funding from Regional Ministry of Health of Andalucia (BOJA nº149 de fecha 30/07/2007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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