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Supplemental Information

TCGA sample IDs of 477 papillary thyroid cancer patients with microRNA and gene expression data

DOI: 10.7287/peerj.preprints.1535v1/supp-1

181 significantly deregulated miRNAs with respective log2 fold change and p value in PTC LNM-P versus PTC LNN

DOI: 10.7287/peerj.preprints.1535v1/supp-2

78 significantly deregulated miRNAs with respective log2 fold change and p value in PTCs (LNM-P and LNN) versus normal thyroid

DOI: 10.7287/peerj.preprints.1535v1/supp-3

407 significantly deregulated genes with respective log2 fold change and p value in PTC LNM-P versus PTC LNN

DOI: 10.7287/peerj.preprints.1535v1/supp-4

Heat Map of the 395 Differentially Expressed miRNAs in PTC LNM-P versus normal thyroid. (Student's T-test with BH corrected p value ≤0.05)

DOI: 10.7287/peerj.preprints.1535v1/supp-5

Heat Map of the 400 Differentially Expressed miRNAs in PTC LNN versus normal thyroid. (Student's T-test with BH corrected p value ≤0.05)

DOI: 10.7287/peerj.preprints.1535v1/supp-6

Top 20 mixed regulatory circuits, involving miRNAs, genes and TFs

There are two types of mixed regulatory circuits; a TF regulating both a given miRNA and its target gene and a miRNA that regulates both a given TF and its regulated gene. (A) PTC LNM-P compared to PTC LNN. (B) PTC LNM-P compared to normal thyroid. (C) PTC LNN compared to normal thyroid.

DOI: 10.7287/peerj.preprints.1535v1/supp-7

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Nurul-Syakima Ab Mutalib conceived and designed the experiments, performed the experiments, wrote the paper, prepared figures and/or tables.

Sri Noraima Othman analyzed the data, contributed reagents/materials/analysis tools.

Azliana Mohamad Yusof analyzed the data.

Shahrun Niza Abdullah Suhaimi wrote the paper, reviewed drafts of the paper.

Rohaizak Muhammad wrote the paper, reviewed drafts of the paper.

Rahman Jamal wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

The research in this article did not generate any raw data. The data is owned by a third-party who has not given their permission to publish as part of this manuscript.

Funding

This manuscript was supported by Fundamental Research Grant Scheme (FRGS) from the Ministry of Education Malaysia (FRGS/1/2014/SKK01/UKM/03/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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