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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Catarina Vizetto-Duarte conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Luísa Custódio conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Gerardo Acosta performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

João H G Lago conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Thiago R Morais performed the experiments, prepared figures and/or tables, reviewed drafts of the paper.

Carolina Bruno de Sousa performed the experiments, prepared figures and/or tables, reviewed drafts of the paper.

Katkam N Gangadhar performed the experiments, analyzed the data, prepared figures and/or tables, reviewed drafts of the paper.

Maria João Rodrigues performed the experiments, prepared figures and/or tables, reviewed drafts of the paper.

Hugo Pereira performed the experiments, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Raquel T Lima performed the experiments, prepared figures and/or tables, reviewed drafts of the paper.

M. Helena Vasconcelos conceived and designed the experiments, analyzed the data, reviewed drafts of the paper.

Luísa Barreira conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Amélia P Rauter conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Fernando Albericio conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, reviewed drafts of the paper.

João Varela conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding data availability:

https://www.dropbox.com/sh/bj7v8uvd6epxchd/AABF6BvZg65AJawzw32g4k9Ba?dl=0

Funding

Foundation for Science and Technology (FCT, Portugal) via the following grants: PTDC/MAR/103957/2008, PTDC/MAR-EST/4346/2012, CCMAR/Multi/04326/2013, SFRH/BD/81425/2011, SFRH/BD/78062/2011, SFRH/BD/105541/2014, SFRH/BPD/81882/2011, IF/00049/2012, SFRH/BPD/68787/2010 Funding was also received from CAPES (Ministry of Education, Brazil) and CNPq (National Council for Technological and Scientific Development, Brazil ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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