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Supplemental Information

Additional Information

Competing Interests

Jun Chen is an Academic Editor for PeerJ.

Author Contributions

Jun Chen analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Euijung Ryu contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Matthew Hathcock contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Karla Ballman contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Nicholas Chia conceived and designed the experiments, performed the experiments, analyzed the data, reviewed drafts of the paper.

Janet E Olson contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Heidi Nelson conceived and designed the experiments, wrote the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Mayo Clinic IRB #13-003694

Data Deposition

The following information was supplied regarding data availability:

http://www.ncbi.nlm.nih.gov/bioproject/PRJNA297510

Accession: PRJNA297510

Funding

Center for Individualized Medicine at the Mayo Clinic (http://mayoresearch.mayo.edu/center-for-individualized-medicine/) and NIH 1R01CA179243. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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