Analgesic efficacy and associated plasma concentration of tramadol and O-desmethyltramadol following oral administration post ovariohysterectomy in dogs

College of Veterinary Medicine, University of Minnesota, SAINT PAUL, MN, United States
Royal Dick School of Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom
DOI
10.7287/peerj.preprints.1510v1
Subject Areas
Anesthesiology and Pain Management, Evidence Based Medicine, Pharmacology, Surgery and Surgical Specialties
Keywords
Tramadol, O-desmethyltramadol, pharmacokinetics, post-operative, ovariohysterectomy, pain, pain score, plasma concentration, dog
Copyright
© 2015 Goudie-DeAngelis et al.
Licence
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
Cite this article
Goudie-DeAngelis EM, Woodhouse KJ. 2015. Analgesic efficacy and associated plasma concentration of tramadol and O-desmethyltramadol following oral administration post ovariohysterectomy in dogs. PeerJ PrePrints 3:e1510v1

Abstract

Tramadol is used in both human and veterinary medicine to treat postoperative pain. The purpose of this study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol was randomly assigned and administered to 14 mixed breed female dogs after ovariohysterectomy. The Short-Form of the Glasgow Composite Measure Pain Scale was used for pain evaluation post-operatively. Plasma was collected for evaluation of tramadol and O-desmethyltramadol concentrations. The effect of weight and dose on pain scores as well as how pain score correlated with plasma concentration of tramadol and O-desmethyltramadol was evaluated. A significant difference in pain score was noted between doses when weight classes were pooled. The plasma concentrations did not correlate with pain score. Based on our results, the use of tramadol as a sole analgesic agent provides inadequate postoperative pain control.

Author Comment

This is a submission to PeerJ for review.

Supplemental Information

raw plasma concentration data

DOI: 10.7287/peerj.preprints.1510v1/supp-1