Study of gallbladder cancer in the light of proteomics
- Subject Areas
- Gallbladder, proteomics, cancer
- © 2015 Pradhan et al.
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Study of gallbladder cancer in the light of proteomics. PeerJ PrePrints 3:e1357v2 https://doi.org/10.7287/peerj.preprints.1357v2
Gallbladder carcinoma (GBC) is a chronic malignancy of the gall bladder and intrahepatic and extrahepatic common bile ducts with a high mortality rate and forms the fifth common cancer of gastrointestinal tract globally. Women remain at higher risk than men and recent studies have reported the highest rate of incidence in women from Delhi, India. GBC treatment suffers from the disadvantage of lack of suitable biomarkers for early diagnosis of the disease. Different proteomic approaches including (i) 2D gel electrophoresis (ii) Mass spectroscopic studies (iii) Isobaric tags for relative and absolute quantization (iTRAQ) -based quantitativeproteomicsstudies are being employed for detection of biomarkers in order to undertake early diagnosis of the disease. In this review we focus on (i) risk factors in GBC, (ii) diagnosis and treatment, (iii) molecular markers, and (iv) proteomic studies in GBC. The future scope of this review lies in the identifying biomarkers of GBC, and may provide directions to unraveling future implications in disease treatment.
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