S-nitrosylation-impaired autophagy: An alternative mechanism underlying aging?
Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, China
- Published
- Accepted
- Subject Areas
- Cell Biology, Diabetes and Endocrinology, Metabolic Sciences, Neurology, Pathology
- Keywords
- S-nitrosylation, autophagy, nitric oxide, nitric oxide synthase, aging, age-related diseases
- Copyright
- © 2013 Zeng
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Cite this article
- 2013. S-nitrosylation-impaired autophagy: An alternative mechanism underlying aging? PeerJ PrePrints 1:e121v1 https://doi.org/10.7287/peerj.preprints.121v1
Abstract
Aging is mysterious with unknown managing patterns. A surprising finding on the tune mode of autophagy by S-nitrosylation is a distinctive step towards the interpretation of the mechanism underlying aging and age-related diseases. This commentary article will discuss, in a wider sense, the implications of S-nitrosylation- and nitration-switched dysfunction of proteins/enzymes in neurodegenerative disorders including Alzheimer's disease (AD), Huntington's diseases (HD) and Parkinson's disease (PD).