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Additional Information

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Linxi Li performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Xin Feng analyzed the data.

Fang Xie performed the experiments.

Jingmin Gu performed the experiments.

Yu Gao performed the experiments, contributed reagents/materials/analysis tools.

Liancheng Lei conceived and designed the experiments, contributed reagents/materials/analysis tools, wrote the paper.

Wenyu Han conceived and designed the experiments.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The care and treatment of mice and pigs in our study were conducted in accordance with the guidelines on animal experimentation of Jilin University (No. 2011044).

Grant Disclosures

The following grant information was disclosed by the authors:

This work was supported by National Natural Science Foundation of China (No. 31072133), the Basic Research and Operating Expenses of Jilin University (No. 421030300101) and the Special Purpose Scientific Research of Doctor Subject Foundation of Chinese Ministry of Education (20060183054).

Funding

This work was supported by National Natural Science Foundation of China (No. 31072133), the Basic Research and Operating Expenses of Jilin University (No. 421030300101) and the Special Purpose Scientific Research of Doctor Subject Foundation of Chinese Ministry of Education (20060183054). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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