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Additional Information

Competing Interests

We inform that Sune Pletscher­-Frankild is currently employed by Ferring Pharmaceuticals, Christian Stolte and Seán I. O’Donoghue are employees of CSIRO, and Seán I. O’Donoghue is an employee of Garvan Institute of Medical Research.

Author Contributions

Alberto Santos conceived and designed the experiments, analyzed the data, prepared figures and/or tables, reviewed drafts of the paper.

Kalliopi Tsafou conceived and designed the experiments, wrote the paper, reviewed drafts of the paper.

Christian Stolte prepared figures and/or tables, reviewed drafts of the paper.

Sune Pletscher-Frankild contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Seán I O’Donoghue prepared figures and/or tables, reviewed drafts of the paper.

Lars Juhl Jensen conceived and designed the experiments, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Data Deposition

The following information was supplied regarding the deposition of related data:

The data and the code used to get the fold enrichment analyses and to generate all the figures in the manuscript can be downloaded at:

http://dx.doi.org/10.6084/m9.figshare.1409446

Data S1 – Mapping of tissue names to Brenda Tissue Ontology terms:

http://dx.doi.org/10.6084/m9.figshare.1405677

Data S2 - Common associations transcriptomic methods

http://dx.doi.org/10.6084/m9.figshare.1405678

Data S3 - mRNA reference set associations

http://dx.doi.org/10.6084/m9.figshare.1405666

Data S4 - Common and unique gene–tissue associations to all the sets

http://dx.doi.org/10.6084/m9.figshare.1405679

Data S5 - Gene–Tissue associations coverage and quality analysis

http://dx.doi.org/10.6084/m9.figshare.1405680

Figure S1. Complementary annotations from text-mining http://dx.doi.org/10.6084/m9.figshare.1405672

Figure S2. Quality and coverage.

http://dx.doi.org/10.6084/m9.figshare.1405673

Figure S3. Score calibration.

http://dx.doi.org/10.6084/m9.figshare.1405674

Funding

This work was in part supported by the Novo Nordisk Foundation Center for Protein Research [NNF14CC0001], by the National Institutes of Health [U54 CA189205-01], and by CSIRO’s OCE Science Leader program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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